Title: Monoclonal antibody binding to EGFR
Tools: VMD, 3ds Max, After Effects
Target Audience: Biomedical researchers and investors
Background: The epidermal growth factor receptor (EGFR) is a cell surface receptor commonly targeted in cancer therapy. The activation of EGFR gives signals that cause the cells to grow and proliferate. This illustration was based on the mechanism of action of cetuximab, which binds to EGFR to inhibit cell growth signals.
Li, S., Schmitz, K. R., Jeffrey, P. D., Wiltzius, J. J., Kussie, P., & Ferguson, K. M. (2005). Structural basis for inhibition of the epidermal growth factor receptor by cetuximab. Cancer Cell, 7(4), 301-311.
Sliwkowski, M. X., & Mellman, I. (2013). Antibody therapeutics in cancer. Science (New York, N.Y.), 341(6151), 1192-1198.